Drug-induced Platelet Antibodies
نویسنده
چکیده
Hypersensitivity to drugs may lead to the development of drug-induced platelet antibodies and consequently thrombocytopenia and bleeding, usually in the form of purpura. The association of drug and purpura was reported by Vipan(1) even before the role of platelets in haemostasis was recognised. The relationship between drug ingestion and thrombocytopenia was demonstrated by Rosenthal in 1928 when he rechallenged a patient who had just recovered from quinine-induced thrombocytopenia
منابع مشابه
Drug-antibody-platelet interaction in quinine- and quinidine-induced thrombocytopenia.
Binding of quinine- and quinidine-dependent antibodies to platelets was studied using an electroimmunoassay to measure platelet-bound IgG. Antibodies from four patients with drug-induced thrombocytopenia differed significantly in their interaction with platelets: association constants for binding to platelets at high drug concentrations ranged from 0.29 to 2.6 x 10(7) M(-1), the maximum number ...
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